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Lancet article (www.thelancet.com) - Effect of age on decisions about the numbers of embryos to transfer in assisted conception: a prospective study.

4 Cell Embryo
Prof Nelson and his colleague Prof Debbie Lawlor have published this important article in the Lancet this week (Thurs 12th Jan 2012).
This study is based on Human Fertilisation and Embryology Authority (HFEA) data and investigated whether livebirth outcomes varied by the number of embryos transferred in relation to maternal age. The main question was whether elective single-embryo transfer should be restricted to young women only.

For a number of years, elective single-embryo transfer has been proposed as a strategy to reduce the risk of multiple birth and adverse pregnancy outcomes after in-vitro fertilisation (IVF). The HFEA have in fact been setting annual maximum multiple birth targets for IVF clinics the UK since 2008. Prof Nelson has concluded through this study that the transfer of 3 embryos in any patient does not show an increase in livebirths and that the decision to transfer one or two embryos should be based on a number of factors and not just patient age.

Prof Nelson comments: ‘This is the next step in the individualisation of IVF treatment which we have been pioneering at GCRM for several years’.

GCRM – pioneers of individualised patient treatment

GCRM has been at the forefront of the individualisation of patient treatment since it opened in 2006. From the use of AMH testing and the subsequent tailoring of each patients proposed stimulation regime, to consideration of the number of embryos to transfer based on each patient’s own circumstances, GCRM has continually strived to increase the success rate of treatment whilst ensuring patient safety. These important developments have only been made possible by the unique environment GCRM has established with Prof Richard Fleming in post as Scientific Director and its strong academic links with Glasgow University and Prof Scott Nelson.